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pentobarbital will reduce the extent or effect of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will decrease the extent or effect of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.pentobarbital decreases levels of vandetanib by influen